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American Society of Microbiology ABMM Sample Questions:

1. A clinical laboratory performs a cefoxitin disk diffusion test on a Staphylococcus aureus isolate from a wound culture. The zone of inhibition measures 18 mm. According to current CLSI M100 guidelines, how should this result be interpreted regarding oxacillin/methicillin susceptibility?

A) Indeterminate (requires mecA gene testing)
B) Resistant (report oxacillin as resistant; infer MRSA)
C) Susceptible (report oxacillin as susceptible)
D) Intermediate (requires MIC testing)

2. A patient with a history of travel to a rural area develops a febrile illness with jaundice and dark urine.
Peripheral blood smear reveals intraerythrocytic parasites with a characteristic Maltese cross morphology.
The MOST likely causative agent is:

A) Babesia microti
B) Trypanosoma brucei
C) Plasmodium falciparum
D) Plasmodium vivax

3. Which virus is recognized as the leading cause of sporadic, severe gastroenteritis in infants and young children globally, for which effective vaccines are now available?

A) Enteric Adenovirus (serotypes 40, 41)
B) Norovirus
C) Astrovirus
D) Rotavirus

4. A clinical microbiology laboratory is monitoring the emergence of antimicrobial resistance. The detection of a bacterial isolate with reduced susceptibility to multiple classes of antibiotics, often due to horizontal gene transfer of resistance determinants, is characteristic of:

A) A naturally competent organism.
B) An intrinsically resistant organism.
C) A pan-susceptible organism.
D) A multidrug-resistant (MDR) organism.

5. During the processing of stool specimens for ova and parasite examination, the formalin-ethyl acetate concentration procedure primarily serves to:

A) Preserve parasite morphology and kill bacteria
B) Separate parasites from fecal debris and concentrate them
C) Stain parasite nuclei for easier identification
D) Selectively culture protozoan trophozoites

Solutions: